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SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 4 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Highly relevant to anticoagulant development
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
Most Useful Reviews
9
Lowers cholesterol
No flushing issues; the effect is decent, so I’ll keep taking it. Niacin is known for reducing blood lipids and enhancing good cholesterol while lowering bad cholesterol. My family, who has diabetes, is keen on controlling blood lipids without prescriptions. This product doesn’t cause flushing, and my family feels well after a while, with test results improving. I’ll continue observing the effects!
Read More
9.3
Reduces bad cholesterol
I began taking niacin to support my autonomic nerves and have noticed significant effects. I experienced flushing, so I switched to this flush-free version. After a month of taking one tablet daily, I lost 3kg, and my blood tests showed dramatically lowered bad cholesterol and triglycerides. The doctor was surprised at how much it had dropped, especially since my bad cholesterol has always been difficult to control.
Read More
0
Dangerous side effects
My HbA1c increased to 6.3, and my fasting blood sugar rose from 86 to 127 after taking this supplement. I felt nauseous and unwell, experiencing fatigue. This is alarming and dangerous, and there should be clearer warnings for this high dosage. Although I usually appreciate Now Foods, this product has not been beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
9
SCI offers safe anticoagulant potential
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
Highly relevant to anticoagulant development
We explored the effects of a synthetic heparin mimetic known as sulfated chiro-inositol (SCI) on blood clotting mechanisms. This innovative treatment aims to inhibit human factor XIa (FXIa), a key player in the clotting process, while minimizing bleeding risks typically associated with anticoagulants.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
In our study, we synthesized SCI to engage FXIa specifically by targeting its heparin-binding sites. Through various blood coagulation assays and in vivo models, we observed that SCI effectively inhibited FXIa, leading to reduced clot formation without significant safety concerns. In particular, SCI demonstrated potent anticoagulant properties, matching the performance of existing treatments like enoxaparin but at a much lower dosage.
Importantly, our investigations revealed that SCI's effects could be reversed by common antidotes, which adds an important layer of safety. While we noted no major bleeding risks or toxicity in the studies, further research is needed to ensure SCI's efficacy across broader clinical scenarios. Overall, our findings highlight SCI as a promising candidate for safer anticoagulation therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8
9.3
Reduces bad cholesterol
I began taking niacin to support my autonomic nerves and have noticed significant effects. I experienced flushing, so I switched to this flush-free version. After a month of taking one tablet daily, I lost 3kg, and my blood tests showed dramatically lowered bad cholesterol and triglycerides. The doctor was surprised at how much it had dropped, especially since my bad cholesterol has always been difficult to control.
Read More
9
Lowers cholesterol
No flushing issues; the effect is decent, so I’ll keep taking it. Niacin is known for reducing blood lipids and enhancing good cholesterol while lowering bad cholesterol. My family, who has diabetes, is keen on controlling blood lipids without prescriptions. This product doesn’t cause flushing, and my family feels well after a while, with test results improving. I’ll continue observing the effects!
Read More
5.5
Helps with cholesterol
A friend took it and found that it aided in clearing bad cholesterol from the blood.
0
Dangerous side effects
My HbA1c increased to 6.3, and my fasting blood sugar rose from 86 to 127 after taking this supplement. I felt nauseous and unwell, experiencing fatigue. This is alarming and dangerous, and there should be clearer warnings for this high dosage. Although I usually appreciate Now Foods, this product has not been beneficial.
Read More
